75708-8

LOINC 2.82

Bruton tyrosine kinase [Interpretation] in B cells+monocytes by Flow cytometry (FC) Narrative

Btk B cells+mono FC-Imp

Definition

  • Analysis of the Bruton tyrosine kinase (Btk) protein by flow cytometry is performed as a preliminary screen for X-linked agammaglobulinemia (XLA), primarily in male patients (<65 years of age) or female carriers (child-bearing age: <45 years). Since genotype-phenotype correlations are important, BTK gene sequencing [LOINC: 35295-5] is performed when the Btk protein is absent by flow cytometry to confirm the diagnosis of XLA.

Component

  • Bruton tyrosine kinase

Specimen / system

  • B cells+monocytes

Class

  • CELLMARK

Property

  • Imp

Scale

  • Nar

Method

  • Flow cytometry

Related names

  • Bruton's Tyrosine Kinase; Btk; CELL MARKERS; Dynamic; FC; Impression; Impression/interpretation of study; Impressions; Interp; Interpretation; Narrative; Point in time; Random; Report; Tyr; Tyrosine-protein kinase BTK; XLA; X-Linked Agammaglobulinemia

Index terms

  • Bruton's Tyrosine Kinase
  • Btk
  • CELL MARKERS
  • Dynamic
  • FC
  • Impression
  • Impression/interpretation of study
  • Impressions
  • Interp
  • Interpretation
  • Narrative
  • Point in time
  • Random
  • Report
  • Tyr
  • Tyrosine-protein kinase BTK
  • X-Linked Agammaglobulinemia
  • XLA