6p25 and 6q23 and 11q and 8q24 and 9p21 chromosome partial aneuploidy in Blood or Tissue by FISH

6p25+6q23+11q+8q24+9p21 aneup Bld/T FISH

Definition

Malignant melanoma often exhibits abnormal copy number of certain chromosomal regions. The assessment of gains and losses in 6p25, 6q23 11q, 8q24 and 9p21 by fluorescent in situ hybridization (FISH) has been found to be helpful in distinguishing benign from malignant melanocytic lesions. This term was created for the submitter's assay which uses three commercially available probes sets: RREB1/D6Z1/MYB/CCND1 (assessing chromosomes 6 and 11), CDKN2A/D9Z1 (assessing chromosome 9p), and D8Z2/MYC (assessing chromosome 8q). The chromosomal abnormalities in melanoma can be varied, so the combined assay has been found to have a better chance to aid in diagnosis. The findings have some mechanistic implications, with tumor suppressor genes on 9p and oncogene (MYC) on 8q.

6p25+6q23+11q+8q24+9p21 aneup; Blood; Chromosom; Chromosomes; Document; Finding; Findings; Fluorescent in situ hybridization; Genetics; Heredity; Heritable; Inherited; Melanoma; Molecular pathology; MOLPATH; MOLPATH.MUTATIONS; Point in time; Random; Tissue; Tissue, unspecified; WB; Whole blood; Whole blood or Tissue