Breast cancer 10-year risk of distant recurrence classification [Interpretation] Qualitative by Prosigna

Brst ca 10Y dist recur class Prosigna

Definition

The risk classification is an ordinal risk category (low, intermediate, high) that indicates a patient's risk of recurrence of breast cancer at 10 years. The classification is based on the 10-year risk of distant recurrence score and lymph node status. Low risk is associated with a 3% chance (confidence interval 2-6%), intermediate risk is associated with a 10% chance (confidence interval 7-14%), and high risk with a 16% chance (confidence interval 11-22%) of distant breast cancer recurrence at 10 years, respectively. [PMID: 24347518] This term was created for the Prosigna™ Breast Cancer Prognostic Gene Signature assay, which is intended for use in postmenopausal women with node-negative (Stage I or II) or node-positive (Stage II), hormone receptor-positive (HR+) breast cancer who have undergone surgery and are to be treated with adjuvant endocrine therapy alone.

breast cancer; Brst ca 10Y risk dist recur class; Impression; Impression/interpretation of study; Impressions; Interp; Interpretation; Molecular pathology; MOLPATH; Ordinal; PAM50; Point in time; Prosigna; Psoriasis Care Satisfaction questionnaire; Ql; Qual; Qualitative; Random; Screen