Breast cancer 10-year risk of distant recurrence panel by Prosigna

Brst ca 10Y risk dist recur Pnl Prosigna

Definition

A 10-year breast cancer distant recurrence risk panel created for the Prosigna™ Breast Cancer Prognostic Gene Signature assay, which is intended for use in postmenopausal women with node-negative (Stage I or II) or node-positive (Stage II), hormone receptor-positive (HR+) breast cancer who have undergone surgery and are to be treated with adjuvant endocrine therapy alone. The panel includes terms for primary tumor size, lymph node status, distant recurrence risk score, and distance recurrence risk classification. The 10-year breast cancer distant recurrence risk score (also referred to as ROR Score or Risk of Recurrence Score) is a numerical score on a scale of 0 -100 that is calculated using a statistical model that includes: 1) the results from a 50-gene expression assay performed on formalin fixed paraffin embedded breast tumor tissue previously diagnosed as invasive carcinoma; 2) proliferation score; and 3) gross tumor size. The calculated score and information about lymph node status are used together to classify the patient into a risk category for distant breast cancer recurrence at 10 years.

breast cancer; Brst ca10Y risk dist recur Pnl; Molecular pathology; MOLPATH; PAM50; Pan; Panel.molpath; Panl; Pnl; Point in time; Prosigna; Psoriasis Care Satisfaction questionnaire; Random