Hepatocyte growth factor receptor Ag [Presence] in Tissue by Immune stain

HGFR Ag Tiss Ql ImStn

Definition

The stain is interpreted as positive if 50% or more of the tumor cells show moderate to strong (2+, 3+) membranous staining, indicating MET amplification. MET amplification (positive) has been seen in approximately 22% of non-small-cell lung cases with acquired resistance to anti-EGFR inhibitors. Recent Phase II clinical trails (OAM4558g) results were released at ASCO in 2011 showed that patients who were c-MET positive (2+ or 3+) lived twice as long without disease progression (PFS) when they received MetMAb therapy in combination with erlotinib versus receiving erlotinib alone.

Antigen; Antigens; c-Met; Fac; Fact; Hepatopoietin A; HGF; HGFR; IHC; Imm; Immunohistochemical stain; Immunostain; ImStn; Imun; Imune; mesenchymal-epithelial transition; MET; Ordinal; PATHOLOGY; Point in time; PR; QL; Qual; Qualitative; Random; Rec; Recept; Receptors; Recp; Recptr; Scatter factor; Scatter Factor Receptor; Screen; SFR; St; Stains; Stn; Tissue; Tissue, unspecified; Transmembrane tyrosine kinase receptor; Tyrosine-protein kinase Met

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