77349-9

LOINC 2.82

Everolimus [Mass/volume] in Blood by LC/MS/MS --trough

Everolimus Trough Bld LC/MS/MS-mCnc

Definition

  • Trough blood levels of everolimus is performed for therapeutic monitoring and dose individualization. Koster et. al. (2009) reported a systematic deviation in blood levels of everolimus (30% lower) measured by LC-MS/MS compared with immunoassays.[PMID: 19065123] Everolimus may be used to treat patients post transplant (e.g, kidney transplant) or with tuberous sclerosis complex (TSC) who have subependymal giant cell astrocytoma (SEGA). Maintaining everolimus troughs between 3-8 ng/mL is recommended for patients post transplant. Maintaining trough levels of 5 to 15 ng/mL is recommended in pediatric and adult patients with SEGA.

Component

  • Everolimus^trough

Specimen / system

  • Bld

Class

  • DRUG/TOX

Property

  • MCnc

Scale

  • Qn

Method

  • LC/MS/MS

Related names

  • Afinitor; Blood; Certican; DRUG/TOXICOLOGY; Drugs; Level; Mass concentration; Point in time; Pre; Predose; Pre-dose; QNT; Quan; Quant; Quantitative; RAD-001; Random; WB; Whole blood; Zortress

Index terms

  • Afinitor
  • Blood
  • Certican
  • DRUG/TOXICOLOGY
  • Drugs
  • Everolimus^trough
  • Level
  • Mass concentration
  • Point in time
  • Pre
  • Pre-dose
  • Predose
  • QNT
  • Quan
  • Quant
  • Quantitative
  • RAD-001
  • Random
  • WB
  • Whole blood
  • Zortress