Noninvasive colorectal cancer DNA and occult blood screening [Presence] in Stool

Noninv colon ca DNA+occ bld scrn Stl Ql

Definition

This term was created for, but is not limited in use to, Exact Sciences' Cologuard DNA screening test for colorectal cancer. The Cologuard algorithm includes two laboratory procedures performed on a single stool specimen: 1) detection and quantification of fecal occult blood using ELISA; and 2) detection of multiple genetic biomarkers (NDRG4 and BMP3 methylation targets, seven KRAS point mutations, and beta actin as a proxy for the total amount of human DNA in each sample) using magnetic bead based oligonucleotide hybrid capture to isolate the biomarkers followed by quantitative real-time target and signal amplification. The occult blood and genetic biomarker results are subsequently entered into a logistic regression model, and the results from this model are used to calculate a composite score from which the final binary result (positive, negative) is determined. [PMID: 24645800]

Asympt; Asymptomatic; Bowel movement; Deoxyribonucleic acid; Faecal; Faeces; Fecal; Feces; Molecular pathology; MOLPATH; Noninv colon ca DNA+occ bld screen; Occ; Ordinal; Point in time; PR; QL; Qual; Qualitative; Random; Scn; Screen; Stl; Stool = Fecal