Calculated panel reactive antibody - Serum

cPRA Ser Calc

Definition

A patient's "calculated panel reactive antibody" (cPRA) determines the likelihood that a transplant recipient and donor would be incompatible. The cPRA is calculated based on how many and which HLA antibodies the patient has compared to known information about the HLA antigen frequencies from ~1200 donors from 2003-2005.[PMID: 19958328] The more antibodies the patient has and the more common the HLA antigens are in the donor pool, the higher the cPRA. Calculated cPRA is not the same as a patient's percent PRA, which is simply the percentage of a pool of donors (~100) to which a patient had reactive antibodies (see the HLA Ab panel [LOINC: 46993-2]). Note that "panel" is part of the antibody name and a single result is expected. This is not panel term.

Ab; Calc; Calculation; cPRA; HLA ANTIGEN; Human Leukocyte Antigen; Pan; Panl; Pnl; Point in time; QNT; Quan; Quant; Quantitative; Random; Reac; React; Relative ratio; Serum; SR