Zika virus neutralizing antibody [Presence] in Serum by Neutralization test

ZIKV NAb Ser Ql Nt

Definition

Qualitative result for Zika virus neutralizing antibodies in serum. Serological cross-reactivity is strong between Zika and other flaviviruses, especially Dengue virus. Therefore, positive EIA or IF assays for Zika virus IgM antibodies are presumptive only and should be confirmed by a neutralization assay, such as the plaque-reduction neutralization test (PRNT), which can discriminate between Zika virus and cross-reacting antibodies in primary flavivirus infections. Recent Zika virus infection is confirmed by stable high neutralizing antibody titers, seroconversion, or a 4x or greater increases in neutralizing antibody titer in a patient's appropriately timed acute and convalescent phase sera.

ABS; Aby; Antby; Anti; Antibodies; Antibody; Autoantibodies; Autoantibody; Conventional virus neutralization test; cVNT; ID; Infectious Disease; InfectiousDisease; Microbiology; NAb; NEUTRALIZATION; Neutralization test; NT; Ordinal; Point in time; PR; QL; Qual; Qualitative; Random; Screen; Serum; Serum virus neutralization; SR; SVN; Virus neutralization test; VNT; Zika virus Nab; ZIKV