von Willebrand factor (vWf) ristocetin cofactor/von Willebrand factor (vWf) Ag [Ratio] in Platelet poor plasma

vWf:RCo/vWF Ag PPP-Rto

Definition

This term represents a ratio of two results that are expressed as percentages of normal: the von Willebrand factor.ristocetin cofactor activity and the von Willebrand factor antigen concentration, both of which are reported as actual/Normal. The von Willebrand factor (vWF) ristocetin cofactor activity to antigen ratio can help distinguish different types of von Willebrand disease (VWD). VWD types 1 and 3 are usually associated with a quantitative decrease in vWF, which would affect both the vWF ristocetin cofactor activity as well as vWF antigen concentration, while type 2 is associated with a functional defect in VWF, which would affect the activity but not the amount of antigen present. Therefore, patients with type 2 VWD are likely to have a lower vWF ristocetin cofactor activity to antigen ratio (less than 0.6-0.7) compared to patients with types 1 or 3 VWD.

Activ; Actvty; AggRecetin; COAGULATION; Cofact; Fac; Fact; Hematology; Heme; Movements; Plas; Platelet poor plasma; Point in time; QNT; Quan; Quant; Quantitative; Random; Ratios; Risto; Rto; Von will; Von willebrand factor activity; Vonwillebrand; vWf; vWf Activity; vWF:Ag; vWf:RCo