t(11;22)(q24;q12.2)(FLI1,EWSR1) and t(21;22)(q22.3;q12.2)(ERG,EWSR1) fusion transcript in Blood or Tissue by Molecular genetics method

EWSR1-FLI1 + EWSR1-ERG Bld/T

Definition

Rearrangements of the EWSR1 gene at 22q12 with FLI1 at 11q24 or ERG at 21q22 collectively occur in about 95% of Ewing sarcoma (EWS) and primitive neuroectodermal tumors (PNET), both types of small round-cell tumors. The fusion transcripts can be detected by various methods, including reverse transcriptase PCR and FISH. A positive result is consistent with a diagnosis of EWS/PNET. A negative result does not rule out the presence of fusion transcripts that may be present, but below the detection limit of an assay.

t(11;22)(q24;q12.2)(FLI1,EWSR1) & t(21;22)(q22.3;q12.2)(ERG,EWSR1) fusion transcript

Blood; DNA; Document; Ewing sarcoma breakpoint region 1; Ewing sarcoma breakpoint region 2; EWS; EWSCR; EWSR1-FLI1 + EWSR1-ERG; EWSR2; Finding; Findings; Friend leukemia virus integration 1; gene fusion; gene translocation; Genetics; Heredity; Heritable; Inherited; Molecular genetics; Molecular pathology; MOLPATH; MOLPATH.TRANSLOCATION; PCR; Point in time; Random; RNA; SIC-1; T prime; t(11,22)(FLI1,EWSR1) gene translocation; t(11;22)(FLI1,EWSR1); t(21,22)(ERG,EWSR1) gene translocation; t(21;22)(ERG,EWSR1); Tissue; Tissue, unspecified; translocation; WB; Whole blood; Whole blood or Tissue

22)(ERG,EWSR1)
22)(FLI1,EWSR1)
Blood
DNA
Document
Ewing sarcoma breakpoint region 1
Ewing sarcoma breakpoint region 2
EWS
EWSCR
EWSR1-FLI1 + EWSR1-ERG
EWSR2
Finding
Findings
Friend leukemia virus integration 1
gene fusion
gene translocation
Genetics
Heredity
Heritable
Inherited
Molecular genetics
Molecular pathology
MOLPATH
MOLPATH.TRANSLOCATION
PCR
Point in time
Random
RNA
SIC-1
T prime
t(11
t(11,22)(FLI1,EWSR1) gene translocation
t(11;22)(q24;q12.2)(FLI1,EWSR1) & t(21;22)(q22.3;q12.2)(ERG,EWSR1) fusion transcript
t(21
t(21,22)(ERG,EWSR1) gene translocation
Tissue
Tissue, unspecified
translocation
WB
Whole blood

1 further terms