Thyroid secretory capacity [Moles/time] in Serum or Plasma by Calculated.SPINA

Thyr secr cap SerPl Calc SPINA-sRate

Definition

Thyroid secretory capacity (also called thyroid output or GT) is the maximum secretion rate of the thyroid gland under stimulated conditions. The structure parameter inference approach (SPINA) uses Michaelis-Menten functions and pharmakokinetic data to estimate GT under conditions of substrate saturation. One calculation is based on peripheral TSH, free T4, thyroid binding globulin and thyroid binding prealbumin values, and an alternate calculation uses peripheral TSH and total T4. GT calculated using the SPINA approach is also known as SPINA-GT. SPINA-GT may be useful in diagnosing secondary or tertiary thyroid conditions and has also been shown to be able to clearly differentiate between euthyroidism and functional thyroid disorders of primary origin. [PMID: 27375554] Peripheral deiodinase activity by SPINA, called SPINA-GD, is a related result [LOINC: 82367-4].

Calc; Calc SPINA; Calculation; Chemistry; Pl; Plasma; Plsm; Point in time; QNT; Quan; Quant; Quantitative; Random; SerP; SerPl; SerPlas; Serum; Serum or plasma; SPINA-GT; SR; sRate; Substance Rate; Thyr secr cap; Thyroid capacity; Thyroid output