82937-4

LOINC 2.82

SAP and XIAP [Interpretation] in Leukocytes by Flow cytometry (FC)

SAP + XIAP WBC FC-Imp

Definition

  • Analysis of SLAM (signaling lymphocytic activation molecule)-associated protein (SAP) and X-linked inhibitor of apoptosis protein (XIAP) levels by flow cytometry is performed as a preliminary screen for X-linked lymphoproliferative (XLP) disease and X-linked familial hemophagocytic lymphohistiocytosis (HLH). If SAP protein levels are absent or decreased, XLP is suspected. If XIAP protein levels are absent or decreased, HLH (aka XLP-2) is suspected. The diagnosis is confirmed by genetic analysis of the associated genes (SH2D1A gene for XLP, BIRC4 gene for HLH).

Component

  • Signaling lymphocytic activation molecule (SLAM)-associated & X-linked inhibitor of apoptosis protein

Specimen / system

  • WBC

Class

  • CHEM

Property

  • Imp

Scale

  • Nom

Method

  • Flow cytometry

Related names

  • (SLAM)-associated protein; Assoc; BIRC4; Chemistry; Duncan disease; Dynamic; Esoteric; FC; Hemophagocytic Lymphohistiocytosis; HLH; Impression; Impression/interpretation of study; Impressions; Inhib; Inhibit; Interp; Interpretation; Leukocytes; Nominal; Point in time; PR; Prot; Purtilo syndrome; Random; SAP; SAP + XIAP; WBCs; White blood cells; XIAP; X-Linked Lymphoproliferative Disorder; XLP; XLP1; XLP2

Index terms

  • (SLAM)-associated protein
  • Assoc
  • BIRC4
  • Chemistry
  • Duncan disease
  • Dynamic
  • Esoteric
  • FC
  • Hemophagocytic Lymphohistiocytosis
  • HLH
  • Impression
  • Impression/interpretation of study
  • Impressions
  • Inhib
  • Inhibit
  • Interp
  • Interpretation
  • Leukocytes
  • Nominal
  • Point in time
  • PR
  • Prot
  • Purtilo syndrome
  • Random
  • SAP
  • SAP + XIAP
  • Signaling lymphocytic activation molecule (SLAM)-associated & X-linked inhibitor of apoptosis protein
  • WBCs
  • White blood cells
  • X-Linked Lymphoproliferative Disorder
  • XIAP
  • XLP
  • XLP1
  • XLP2