PD-L1 by clone 28-8 [Interpretation] in Tissue by Immune stain Narrative

PD-L1 by 28-8 Tiss ImStn-Imp

Definition

This term should be used to report the narrative impression of PD-L1 (CD274) protein expression in tumor cells as determined by immune staining with anti-PD-L1 clone 28-8. Patients with certain cancers, such as non-squamous non small cell lung cancer (NSCLC) or melanoma, whose tumors are positive for PD-L1 by 28-8 may be eligible for anti-programmed death 1 (PD-1) receptor antibody therapy, which effectively prevents the binding of PD-L1 to PD-1. The percentage of viable tumor cells that show partial or complete PD-L1 membrane staining is reported using [LOINC: 83053-9], and the ordinal staining result using [LOINC: 83055-4]. This term was created for, but is not limited in use to, the Dako PD-L1 28-8 pharmDx test kit, which, as of November 2016, is FDA-approved as a companion diagnostic to assess whether patients with certain cancers are eligible for nivolumab therapy.

B7 homolog 1; B7-H1; CD274; Cluster of differentiation 274; i; IHC; Imm; Immunohistochemical stain; Immunostain; Impression; Impression/interpretation of study; Impressions; ImStn; Imun; Imune; Interp; Interpretation; Narrative; Pathology; PDL1; PD-L1; PD-L1 by 28-8; Point in time; Random; Report; St; Stains; Stn; Tissue; Tissue, unspecified