Cells.chromosome region 5q31 deletion/Cells counted in Bone marrow by FISH

Cells.5q31 Del/Cells NFr Mar FISH

Definition

The percent of cells in bone marrow containing the 5q31 deletion involving the EGR1 gene can be detected by FISH and used for the diagnosis of chronic lymphocytic leukemia (CLL), multiple myeloma as well as other forms of cancer. This term is used to report the number of cells that have the deletion out of total number of cells examined (e.g. 80 out of 100 cells, or 80%). Results are also typically reported in ISCN (International System for Human Cytogenetic Nomenclature) format [LOINC: 62356-1]. This term is based, but not limited in use to, the Vysis LSI EGR1 (5q31) probe, which targets the EGR1 gene and flanking regions.

BM; BON; Bone marrow; Cell; Cells.5q31; Cells.5q31 del; Cellularity; Chromosom; Chromosomes; Cyto loc; Del; Deletions; Fluorescent in situ hybridization; Genetics; Heredity; Heritable; Inherited; MAR; Marrow (bone); minimal angle of resolution; Minimum angle of resolution; Molecular pathology; MOLPATH; MOLPATH.DELDUP; Number Fraction; Percent; Point in time; QNT; Quan; Quant; Quantitative; Random