Cells.chromosome region 13q14 deletion/Cells counted in Blood or Tissue by FISH

Cells.13q14 Del/Cells NFr Bld/T FISH

Definition

Deletions at 13q14 involving the RB1 gene can be detected by FISH and used for the diagnosis of chronic lymphocytic leukemia (CLL), multiple myeloma, non-Hodgkin's lymphoma (NHL) as well as other forms of cancer. Labs will report the number of cells that have the deletion out of total number of cells examined (e.g. 80 out of 100 cells, or 80%). Results are also reported in ISCN (International System for Human Cytogenetic Nomenclature) format [LOINC: 62356-1]. This term is based, but not limited in use to, the Vysis LSI 13 (13q14) probe, which targets the RB1 gene and flanking regions.

Blood; Cell; Cells.13q14; Cells.13q14 del; Cellularity; Chr 13q14; Chr 13q14 deletion; Chromosom; Chromosomes; Cyto loc; Del; Deletions; Fluorescent in situ hybridization; Genetics; Heredity; Heritable; Inherited; Molecular pathology; MOLPATH; MOLPATH.DELDUP; Number Fraction; Percent; Point in time; QNT; Quan; Quant; Quantitative; Random; Tissue; Tissue, unspecified; WB; Whole blood; Whole blood or Tissue