Cells.chromosome region 11q22.3 deletion/Cells counted in Blood or Tissue by FISH

Cells.11q22.3 Del/Cells NFr Bld/T FISH

Definition

Deletions at 11q22.3 involving the ATM gene can be detected by FISH and used for the diagnosis of chronic lymphocytic leukemia (CLL), multiple myeloma as well as other forms of cancer. This term is used to report the number of cells that have the deletion out of total number of cells examined (e.g. 80 out of 100 cells, or 80%). Results are also typically reported in ISCN (International System for Human Cytogenetic Nomenclature) format [LOINC: 62356-1]. This term is based, but not limited in use to, the Vysis LSI ATM (11q22.3) probe, which targets the ATM gene and flanking regions.

Blood; Cell; Cells.11q22.3; Cells.11q22.3 del; Cellularity; Chromosom; Chromosomes; Cyto loc; Del; Deletions; Fluorescent in situ hybridization; Genetics; Heredity; Heritable; Inherited; Molecular pathology; MOLPATH; MOLPATH.DELDUP; Number Fraction; Percent; Point in time; QNT; Quan; Quant; Quantitative; Random; Tissue; Tissue, unspecified; WB; Whole blood; Whole blood or Tissue