Cells.chromosome region 17p13.1 deletion/Cells counted in Blood or Tissue by FISH

Cells.17p13.1 Del/Cells NFr Bld/T FISH

Definition

Deletions at 17p13.1 involving the TP53 gene can be detected by FISH and used for the diagnosis of chronic lymphocytic leukemia (CLL), multiple myeloma as well as other forms of cancer. This term is used to report the number of cells that have the deletion out of total number of cells examined (e.g. 80 out of 100 cells, or 80%). Results are also typically reported in ISCN (International System for Human Cytogenetic Nomenclature) format [LOINC: 62356-1]. This term is based, but not limited in use to, the Vysis LSI p53 (17p13.1) probe, which targets the TP53 gene and flanking regions.

Blood; Cell; Cells.17p13.1; Cellularity; Chr 17p13.1; Chr 17p13.1 del; Chromosom; Chromosomes; Cyto loc; Del; Deletions; Fluorescent in situ hybridization; Genetics; Heredity; Heritable; Inherited; Molecular pathology; MOLPATH; MOLPATH.DELDUP; Number Fraction; Percent; Point in time; QNT; Quan; Quant; Quantitative; Random; Tissue; Tissue, unspecified; WB; Whole blood; Whole blood or Tissue