Presumptive ABO group [Type] in Saliva (oral fluid) by Molecular genetics method

ABO.presumptive Sal by Molgen

Definition

The presumptive (predicted) ABO phenotype based on genetic analysis of the ABO gene. Hematopoietic stem cell transplant donor registries often collect samples from potential donors using buccal swabs or saliva as part of enrolling them in the registry. Because these samples do not contain fresh intact red blood cells (RBCs) and traditional serological ABO typing cannot be done, molecular typing is performed as part of the screening process to find an appropriate hematopoietic stem cell donor. Prior to transfusion or transplantation, the presumptive ABO result based on molecular typing must be confirmed using traditional serologic typing. This term was created for, but not limited in use to, the submitter's lab that performs sequence analysis of exons 6 and 7, at a minimum, in the ABO gene and predicts the ABO phenotype from the resulting DNA sequence.

ABO.presumptive; BLOOD BANK; Hematology; Heme; Molecular genetics; Nominal; Oral fluid; PCR; Point in time; Random; Sal; Typ