Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ and CD8+ T-cells [Units/volume] in Blood

M TBIFN-g CD4+ CD8+T-cells Bld-aCnc

Definition

The quantitative levels (uncorrected for background) for an IFN-gamma response by CD4+ T-helper and CD8+ T cytotoxic lymphocytes stimulated by the presence of TB antigens, specifically ESAT-6 and CFP-10. This term was created for, but not limited in use to, the QuantiFERON-TB Gold Plus test, which includes two tubes with the Mycobacterium tuberculosis (MTB)-complex-associated antigens ESAT-6 and CFP-10 that stimulate a cell-mediated immunity (CMI) response. The first tube contains antigens that stimulate a response from CD4+ T-helper lymphocytes [LOINC: 64084-7], and the second tube (this term) contains the antigens included in tube 1 as well as an additional set of peptides targeting the CMI response from CD8+ cytotoxic T lymphocytes. In the QuantiFERON-TB Gold Plus test, the amount of IFN-gamma is measured by enzyme-linked immunosorbent assay and reported in IU/mL. Results are adjusted for background, heterophile antibody effects, or nonspecific IFN-gamma in blood samples.

Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ and CD8+ T-cells

Acid Fast; Acid Fast Bacilli; Acid fast bacillus; AFB; Arbitrary concentration; Blood; Cell; Cellularity; Helper T cells; ID; IFN; IGRA; Inducer T cells; Infectious Disease; InfectiousDisease; L3T4; Leu2; Leu-2; Leu3; Leu-3; Lung; M tb; M TB IFN-g; M TBIFN-g CD4+ CD8+T-cells; M tuberculosis; Microbiology; Mtb; Myco; Mycobact; Mycobacterium tuberculosum; Point in time; Pulmonary; Pulmonology; QNT; Quan; Quant; Quantitative; Random; Respiratory; Suppressor T cells; T prime; T4; T-4; T8; T-8; TB; Tsuppressor; Tuberculosis; W3/25; WB; Whole blood

11 further terms