Coagulation factor VIII.recombinant.bound/von Willebrand factor (vWf) Ag in Plasma by Immunoassay

Fact VIII.recomb.bound/vWF Ag Plas IA

Definition

This test measures the binding activity of von Willebrand factor (vWF) to Factor VIII as the ratio of the amount of exogenous recombinant Factor VIII bound to vWF in the patient sample to the amount of vWF in the patient sample. It is used to differentiate between various bleeding disorders including hemophilia A and type 2N von Willebrand disease (2N vWD, VWD2N, or Type 2 Normandy). Type 2N vWD is caused by mutations to the Factor VIII binding site of vWF, which results in reduced binding and faster clearance of Factor VIII. Patients with type 2N vWD usually have reduced Factor VIII activity with normal VWF levels. [PMID: 19298374]

AHF; AHG; Antihemophilic factor; Antihemophilic globulin; Associated; bnd; Circulating anticoagulant; Coag; EIA; ELFA; ELISA; Enzyme immunoassay; F8; Fac; Fact; Fact VIII; Fact VIII.recomb.bound; Factor 8; Factor VIII clotting activity; FVIII; Hematology; Heme; IAA; MEIA; Normandy; Pl; Plasma; Plsm; Point in time; QNT; Quan; Quant; Quantitative; Random; Relative ratio; SUDS; Thrombocyte cofactor A; Type 2 Normandy; VIII:C; Von will; Vonwillebrand; vWf; vWF:Ag

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