93690-6

LOINC 2.82

BRAF gene V600 mutations [Identifier] in Plasma cell-free DNA by Molecular genetics method Nominal

BRAF p.V600 mutations Plas.cfDNA

Definition

  • Detection of BRAF V600 variants, including V600E (Val600Glu, c.1799T>A) and V600K (Val600Lys, c.1798_1799delGTinsAA), in cell-free DNA. Using cell-free DNA is alternative to invasive tissue biopsies. The most prevalent mutations are V600E (70−90%) and V600K (5−30%); other mutations are rare. A positive result indicates the presence of an activating BRAF mutation and may be useful for guiding the treatment of individuals with melanoma.

Component

  • BRAF gene.p.Val600 mutations

Specimen / system

  • Plas.cfDNA

Class

  • MOLPATH.MUT

Property

  • Prid

Scale

  • Nom

Method

  • Molgen

Related names

  • BRAF p.V600 mutations; B-Raf proto-oncogene, serine/threonine kinase; BRAF1; B-RAF1; Identity or presence; Molecular genetics; Molecular pathology; MOLPATH; MOLPATH.MUTATIONS; Mut; Mutation; Muts; Nominal; NS7; P prime; PCR; Pl; Plasma; Plsm; Point in time; RAFB1; Random; v-raf

Index terms

  • B-Raf proto-oncogene, serine/threonine kinase
  • B-RAF1
  • BRAF gene.p.Val600 mutations
  • BRAF p.V600 mutations
  • BRAF1
  • Identity or presence
  • Molecular genetics
  • Molecular pathology
  • MOLPATH
  • MOLPATH.MUTATIONS
  • Mut
  • Mutation
  • Muts
  • Nominal
  • NS7
  • P prime
  • PCR
  • Pl
  • Plasma
  • Plsm
  • Point in time
  • RAFB1
  • Random
  • v-raf