95143-4

LOINC 2.82

UGT1A1 gene TA repeats [Genotype] in Blood or Tissue by Molecular genetics method Nominal

UGT1A1 TA Geno Bld/T

Definition

  • The patient's genotype (e.g. TA5/TA7) for the TA repeat variant within the UGT1A1 gene. Variants include TA5 or *36: c.−41_-40delTA (g.234668893_234668894), TA7 or *28: c.−41_-40dupTA (g.234668893_234668894), and TA8 or *37: c.−43_-40dupTATA (g. 234668891_234668894). Testing is performed to screen for variants associated with increased risk of adverse drug reactions when taking UGT1A1-metabolized drugs, including pazopanib, nilotinib, atazanavir, and belinostat. Patient's homozygosity for the TA7 promoter variant (*28) have reduced UGT1A1 activity (about 30% to 50%) compared to normal.[PMID: 7565971]

Component

  • UGT1A1 gene.TA repeats

Specimen / system

  • Bld/Tiss

Class

  • MOLPATH.PHARMG

Property

  • Geno

Scale

  • Nom

Method

  • Molgen

Related names

  • BILIQTL1; Blood; Crigler-Najjar syndrome, type I; Genetics; Gilbert Syndrome; GNT1; Heredity; Heritable; HUG-BR1; Inherited; Ma2; Molecular genetics; Molecular pathology; MOLPATH; MOLPATH.PHARMG; Nominal; PCR; Point in time; Random; Repeat; Tissue; Tissue, unspecified; UDP glucuronosyltransferase 1 family, polypeptide A1; UDP glycosyltransferase 1 family, polypeptide A1 gene; UDPGT; UDPGT 1-1; UGT1; UGT1A; UGT1A1 TA; UGT1A5; WB; Whole blood; Whole blood or Tissue

Index terms

  • BILIQTL1
  • Blood
  • Crigler-Najjar syndrome, type I
  • Genetics
  • Gilbert Syndrome
  • GNT1
  • Heredity
  • Heritable
  • HUG-BR1
  • Inherited
  • Ma2
  • Molecular genetics
  • Molecular pathology
  • MOLPATH
  • MOLPATH.PHARMG
  • Nominal
  • PCR
  • Point in time
  • Random
  • Repeat
  • Tissue
  • Tissue, unspecified
  • UDP glucuronosyltransferase 1 family, polypeptide A1
  • UDP glycosyltransferase 1 family, polypeptide A1 gene
  • UDPGT
  • UDPGT 1-1
  • UGT1
  • UGT1A
  • UGT1A1 gene.TA repeats
  • UGT1A1 TA
  • UGT1A5
  • WB
  • Whole blood
  • Whole blood or Tissue