ERBB2 gene duplication in Tumor by FISH

ERBB2 gene Dp Tumor FISH

Definition

Gene duplication analysis of the ERBB2 gene by FISH studies is performed to guide therapy for patients with primary or metastatic breast tumors. Patients with ERBB2 gene amplification leading to overexpression of the human epidermal growth factor receptor 2 (HER2) protein may be candidates for therapies, such as trastuzumab and pertuzumab, that target HER2. Testing may also be performed to confirm the presence of HER2 amplification in cases with 2+ (low level) or 3+ (high level) HER2 protein overexpression by immunohistochemistry, as well as for certain histologic subtypes with aberrant patterns of HER2 expression seen by immunohistochemistry. The collection of information contained by this term may include the overall result (positive/negative), copy numbers and ratio of HER2 to CEP17, the interpretation, recommendations, and references. For associated observations (result codes) related to this test, see the ERBB2 gene duplication associated observations panel [LOINC: 74885-5].

Amplification; Cancer; CD340; c-erb B2; Document; Dp; ERBB2 duplication; erb-b2 receptor tyrosine kinase 2; Finding; Findings; Fluorescent in situ hybridization; Genetics; HER2; HER-2; HER-2/neu; Heredity; Heritable; Inherited; MLN 19; Molecular pathology; MOLPATH; NEU; NGL; Oncology; Point in time; Random; TKR1; tumors; tumour; tumours; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)

Amplification
c-erb B2
Cancer
CD340
Document
Dp
erb-b2 receptor tyrosine kinase 2
ERBB2 duplication
Finding
Findings
Fluorescent in situ hybridization
Genetics
HER-2
HER-2/neu
HER2
Heredity
Heritable
Inherited
MLN 19
Molecular pathology
MOLPATH
NEU
NGL
Oncology
Point in time
Random
TKR1
tumors
tumour
tumours
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)