Trisomy 13, trisomy 18 or triploidy risk [Interpretation] in Plasma cell-free+WBC DNA Qualitative by calculation

T13+T18+Trip risk WBC.DNA+cfDNA Calc-Imp

Definition

The ordinal interpretation for the combined fetal trisomy 13+trisomy 18+triploidy risk is determined in cases where the SNP-based noninvasive prenatal test did not return a result due to low fetal fraction (FF) or the inability to make a high-confidence call. FF is known to be lower in cases of trisomy 13, trisomy 18 and digynic (maternal) triploidy, but not all cases of low FF is due to aneuploidy. Combined risk calculations may include the FF value, gestational age (GA), maternal weight (MW) and prior risk data to determine the overall risk.[PMID: 30014528]

Calc; Calculation; Edward syndrome; Gyn; Gynecology; Impression; Impression/interpretation of study; Impressions; Interp; Interpretation; Leukocytes; Molecular pathology; MOLPATH; OB; ObGyn; Obstetrics; Ordinal; Pl; Plasma; Plsm; Point in time; QL; Qual; Qualitative; Random; Screen; T13+T18+Trip risk; Ts; WBC.DNA+cfDNA; WBCs; White blood cells