B-cell primary immunodeficiency multigene analysis in Blood or Tissue by Molecular genetics method

B-cell PI multigene Bld/T

Definition

This test includes analysis of multiple genes associated with primary B-cell disorders/humoral immunodeficiencies. Testing is performed for patients with a personal or family history to establish a diagnosis and determine appropriate management of disease based on the gene involved. Targeted genes include, but are not limited to, AICDA, BLNK, BTK, CD79A, CD79B (B29), CARD11, CD19, CD27, CD40, CD40LG, CD81, CR2 (CD21), CXCR4, GATA2, ICOS, IGHM, IGLL1 (Lambda5), IKZF1 (IKAROS), LRBA, LRRC8A, MALT1, MS4A1 (CD20), NFKB2, PIK3R1, PIK3CD, PLCG2, PRKCD, RNF168, SH2D1A, TCF3 (E47), TNFRSF13B (TACI), TNFRSF13C, TNFSF12 (TWEAK), and UNG. The overall collection of information typically includes the gene evaluated, variant(s) detected, interpretation, test methodology, and recommendations.

B Cell; B-ALL; B-cell acute lymphoblastic leukemia; B-cell PI multigene; BCELLS; Blood; Document; Finding; Findings; Gene; Gene panel; Molecular genetics; Molecular pathology; MOLPATH; Multi-gene study; Multiple-gene panel test; PCR; Point in time; Random; Tissue; Tissue, unspecified; WB; Whole blood; Whole blood or Tissue