Hereditary cancer multigene analysis in Blood or Tissue by Molecular genetics method

Hereditary Cancer Multigene Anl Bld/T

Definition

Multigene testing for heritable germline mutations in genes associated with cancer in various organ systems, including breast and gynecologic (breast, ovarian, uterine), gastrointestinal (colorectal, gastric, pancreatic), endocrine (thyroid, paraganglioma/pheochromocytoma, parathyroid, pituitary), genitourinary (renal/urinary tract, prostate), skin (melanoma, basal cell carcinoma), brain/nervous system, and bone/soft tissue (sarcoma) & blood (myelodysplastic syndrome/leukemia). Testing is performed to confirm a diagnosis and help guide treatment and management decisions. Identification of a disease-causing variants may also used to inform at-risk relatives. Approximately 5-10 percent of cancers are thought to be hereditary.[PMID: 15637391] This test is not appropriate for the detection of somatic mutations in tumor tissue since it is focused on heritable germline mutations.

Blood; Document; Finding; Findings; Gene; Gene panel; Gyn; Gynecology; Hereditary Cancer Multigene Anl; Molecular genetics; Molecular pathology; MOLPATH; Multi-gene study; Multiple-gene panel test; OB; ObGyn; Obstetrics; PCR; Point in time; Random; Tissue; Tissue, unspecified; WB; Whole blood; Whole blood or Tissue