97911-2

LOINC 2.82

Endogenous thrombin potential [Area under the curve] in Platelet poor plasma by Chromogenic method --after addition of factor VIII Ab

ETP p FVIII Ab PPP Chro-AUC

Definition

  • The endogenous thrombin potential (ETP) is the area under the curve of a thrombin generation test (TGT). It represents thrombin's total enzyme activity and is the most predictive of bleeding and/or thrombosis risk out of all the TGT measurements. [PMID: 21262433] Measuring the ETP in the presence of Factor VIII antibodies is done to help determine the contribution of Factor VIII to the ETP. If the ETP is significantly decreased in the presence of Factor VIII antibodies, that indicates that Factor VIII had a significant contribution to the baseline ETP. If the ETP does not decrease, then Factor VIII did not have a large contribution. [PMID: 12871369]

Component

  • Endogenous thrombin potential^after addition of Factor VIII Ab

Specimen / system

  • PPP

Class

  • COAG

Property

  • TmSCnc

Scale

  • Qn

Method

  • Chromo

Related names

  • AUC; Chromogenic assay; COAGULATION; ENZY; Enzymatic assay; ETP; F8; Fac; Fact; Fact VIII; Factor 8; FVIII; Hematology; Heme; p FVIII Ab; Plas; Platelet poor plasma; Point in time; QNT; Quan; Quant; Quantitative; Random; Throm

Index terms

  • AUC
  • Chromogenic assay
  • COAGULATION
  • Endogenous thrombin potential^after addition of Factor VIII Ab
  • ENZY
  • Enzymatic assay
  • ETP
  • F8
  • Fac
  • Fact
  • Fact VIII
  • Factor 8
  • FVIII
  • Hematology
  • Heme
  • p FVIII Ab
  • Plas
  • Platelet poor plasma
  • Point in time
  • QNT
  • Quan
  • Quant
  • Quantitative
  • Random
  • Throm