Transient abnormal myelopoiesis

Description

A myeloid proliferation occurring in newborns with Down syndrome. It is clinically and morphologically indistinguishable from acute myeloid leukaemia and is associated with GATA1 mutations. The blasts display morphologic and immunophenotypic features of megakaryocytic lineage. In the majority of patients the myeloid proliferation undergoes spontaneous remission.

Index terms

Transient abnormal myelopoiesis

Exclusions from above levels

2E03 – Malignant neoplasm metastasis in bone or bone marrow
http://id.who.int/icd/entity/501778925 – Malignant neoplasm metastasis in lymph nodes
http://id.who.int/icd/entity/97145147 – Malignant neoplasm metastasis in thymus gland

Sibling codes

2A60.41 – Myeloid leukaemia associated with Down syndrome
2A60.4Y – Other specified myeloid proliferation associated with Down syndrome
2A60.4Z – Myeloid proliferation associated with Down syndrome, unspecified

Foundation entity

Transient abnormal myelopoiesis – http://id.who.int/icd/entity/2082163425

Allowed postcoordination axes

hasManifestation

Part of: 2A60.4: Myeloid proliferation associated with Down syndrome › 2A60: Acute myeloid leukaemias and related precursor neoplasms › 02: Neoplasms