Myeloid proliferation associated with Down syndrome

Description

Myeloid neoplasms occurring in individuals with Down syndrome. There is an increased risk of acute leukaemias in both children and adults with Down syndrome. In particular, the incidence of acute myeloid leukaemia in Down syndrome children of less than five years of age is particularly high, it is usually an acute megakaryoblastic leukaemia, and is associated with GATA1 gene mutation. This group of disorders also includes the entity transient abnormal myelopoiesis which occurs in neonates and is associated with GATA1 gene mutation.

Exclusions from above levels

2E03 – Malignant neoplasm metastasis in bone or bone marrow
http://id.who.int/icd/entity/501778925 – Malignant neoplasm metastasis in lymph nodes
http://id.who.int/icd/entity/97145147 – Malignant neoplasm metastasis in thymus gland

Child codes

2A60.40 – Transient abnormal myelopoiesis
2A60.41 – Myeloid leukaemia associated with Down syndrome
2A60.4Y – Other specified myeloid proliferation associated with Down syndrome
2A60.4Z – Myeloid proliferation associated with Down syndrome, unspecified

Sibling codes

2A60.0 – Acute myeloid leukaemia with recurrent genetic abnormalities
2A60.1 – Acute myeloid leukaemia with myelodysplasia-related changes
2A60.2 – Therapy-related myeloid neoplasms
2A60.3 – Acute myeloid leukaemia, not elsewhere classified by criteria of other types
2A60.5 – Blastic plasmacytoid dendritic cell neoplasm
2A60.Y – Other specified acute myeloid leukaemias and related precursor neoplasms
2A60.Z – Acute myeloid leukaemias and related precursor neoplasms, unspecified

Foundation entity

Myeloid proliferation associated with Down syndrome – http://id.who.int/icd/entity/1587058820

Allowed postcoordination axes

Part of: 2A60: Acute myeloid leukaemias and related precursor neoplasms › 02: Neoplasms