Classical Hodgkin lymphoma

Description

Classical Hodgkin lymphoma is a B-cell lymphoma characterised histologically by the presence of large mononuclear Hodgkin cells and multinucleated Reed-Sternberg (HRS) cells. A monoclonal B-cell lymphoproliferation in the vast majority of cases. It is characterised by a bimodal age distribution (15-30 years of life and late life) and is often associated with EBV infection. In less than 5% of cases it is a monoclonal proliferation of T-lymphocytes. Morphologically, it is characterised by the presence of Reed-Sternberg cells and mononuclear Hodgkin cells. The Reed-Sternberg and mononuclear Hodgkin cells are CD30 positive in nearly all cases and CD15 positive in the majority of cases.

Inclusions

• Classical Hodgkin lymphoma, type not specified

Exclusions from above levels

• 2E03 – Malignant neoplasm metastasis in bone or bone marrow
• http://id.who.int/icd/entity/501778925 – Malignant neoplasm metastasis in lymph nodes
• http://id.who.int/icd/entity/97145147 – Malignant neoplasm metastasis in thymus gland