Alpha-delta dense granule deficiency

Description

A condition caused by determinants arising after birth, in the antenatal period. This condition is characterised by defects in the alpha delta dense granules in platelets, leading to abnormalities in coagulation mechanisms. This condition may present with prolonged bleeding, epistaxis, menorrhagia, easy bruising, anaemia, fatigue or shortness of breath. Confirmation is by identification of low levels of alpha delta dense granules in a blood sample.

Index terms

Alpha-delta dense granule deficiency
deficient alpha granule syndrome
platelet alpha granule deficiency

Exclusions from above levels

3B12 – Von Willebrand disease
JA43.3 – Postpartum coagulation defects
04 – Diseases of the immune system

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05 – Endocrine, nutritional or metabolic diseases
18 – Complications of pregnancy, childbirth or the puerperium
19 – Certain conditions originating in the perinatal period
20 – Congenital malformations, deformations or chromosomal abnormalities
22 – Injury, poisoning or certain other consequences of external causes
http://id.who.int/icd/entity/1000704511 – Human immunodeficiency virus disease
JB64.1 – Other diseases of the blood or blood-forming organs or certain disorders involving the immune mechanism complicating pregnancy, childbirth or the puerperium

Sibling codes

3B62.0 – Inherited qualitative platelet defects
3B62.1 – Bleeding diathesis due to thromboxane synthesis deficiency
3B62.2 – Isolated thrombocytopenia
3B62.3 – Dense granule disease
3B62.Y – Other specified qualitative platelet defects
3B62.Z – Qualitative platelet defects, unspecified

Foundation entity

Alpha-delta dense granule deficiency – http://id.who.int/icd/entity/1557840180

Part of: 3B62: Qualitative platelet defects › 03: Diseases of the blood or blood-forming organs