3B81.B

ICD-11 MMS 2026-01

Hypersplenism

Description

A disease caused by determinants such as cirrhosis, malaria, tuberculosis or inflammatory disorders leading overactive spleen function. This disease is characterised by the presence of an enlarged spleen. Confirmation is by identification through medical imaging.

Index terms

  • Hypersplenism
  • big spleen syndrome
  • hyperfunction of spleen
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  • hypersplenia
  • increased splenic activity
  • spleen metaplasia
  • splenic metaplasia
  • Gamna disease
  • Gandy Nanta disease
  • Splenic primary panhaematopenia
  • Myeloid metaplasia
  • Agnogenic myeloid metaplasia
  • Myelogenous metaplasia

Excludes

  • LB22 – congenital splenomegaly
  • ME10.01 – Splenomegaly, not elsewhere classified

Exclusions from above levels

  • 04 – Diseases of the immune system
  • 05 – Endocrine, nutritional or metabolic diseases
  • 18 – Complications of pregnancy, childbirth or the puerperium
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  • 19 – Certain conditions originating in the perinatal period
  • 20 – Congenital malformations, deformations or chromosomal abnormalities
  • 22 – Injury, poisoning or certain other consequences of external causes
  • http://id.who.int/icd/entity/1000704511 – Human immunodeficiency virus disease
  • JB64.1 – Other diseases of the blood or blood-forming organs or certain disorders involving the immune mechanism complicating pregnancy, childbirth or the puerperium

Sibling codes

  • 3B81.0 – Tumour-like conditions of spleen
  • 3B81.1 – Postsurgical asplenia
  • 3B81.2 – Atrophy of spleen
  • 3B81.3 – Nontraumatic laceration or rupture of spleen
  • 3B81.4 – Splenosis
  • 3B81.5 – Splenic cyst or pseudocyst
  • 3B81.6 – Infarction of spleen
  • 3B81.7 – Infection of spleen
  • 3B81.8 – Torsion of spleen
  • 3B81.9 – Fibrosis of spleen
  • 3B81.A – Perisplenitis
  • 3B81.C – Chronic congestive splenomegaly
  • 3B81.Y – Other specified acquired disorders of spleen
  • 3B81.Z – Acquired disorders of spleen, unspecified

Foundation entity

Hypersplenism – http://id.who.int/icd/entity/2093549625

Part of: 3B81: Acquired disorders of spleen › 03: Diseases of the blood or blood-forming organs