4A43.21

ICD-11 MMS 2026-01

Secondary Sjögren syndrome

Description

Secondary Sjögren syndrome is a progressive inflammatory autoimmune disease affecting the exocrine glands in the presence of other systemic autoimmune diseases, such as rheumatoid arthritis, systemic lupus erythematosus, and systemic sclerosis. Lymphocytic infiltrates replace functional epithelium, leading to oral and ocular dryness.

Index terms

  • Secondary Sjögren syndrome

Exclusions from above levels

  • 02 – Neoplasms
  • 18 – Complications of pregnancy, childbirth and the puerperium
  • 20 – Developmental anomalies

Sibling codes

  • 4A43.20 – Primary Sjögren syndrome
  • 4A43.22 – Paediatric onset Sjögren syndrome
  • 4A43.2Y – Other specified sjögren syndrome
  • 4A43.2Z – Sjögren syndrome, unspecified

Foundation entity

Secondary Sjögren syndrome – http://id.who.int/icd/entity/953143133

Allowed postcoordination axes

Part of: 4A43.2: Sjögren syndrome › 4A43: Overlap or undifferentiated nonorgan specific systemic autoimmune disease › 04: Diseases of the immune system