4B23

ICD-11 MMS 2026-01

Immune reconstitution inflammatory syndrome

Description

This is a condition seen in some cases of AIDS or immunosuppression, in which the immune system begins to recover, but then responds to a previously acquired opportunistic infection with an overwhelming inflammatory response that paradoxically makes the symptoms of infection worse.

Index terms

  • Immune reconstitution inflammatory syndrome
  • IRIS - [immune reconstitution inflammatory syndrome]
  • Immune reconstitution syndrome
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  • HIV-associated immune reconstitution inflammatory syndrome
  • HIV - [human immunodeficiency virus] associated IRIS - [Immune reconstitution inflammatory syndrome]
  • Immune reconstitution inflammatory syndrome [IRIS], HIV-associated

Exclusions from above levels

  • 2A83.0 – Monoclonal gammopathy of undetermined significance
  • NE84 – Failure or rejection of transplanted organs or tissues
  • 02 – Neoplasms
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  • 18 – Complications of pregnancy, childbirth and the puerperium
  • 20 – Developmental anomalies

Sibling codes

  • 4B20 – Sarcoidosis
  • 4B21 – Polyclonal hypergammaglobulinaemia
  • 4B22 – Cryoglobulinaemia
  • 4B24 – Graft-versus-host disease
  • 4B2Y – Other specified disorders involving the immune system

Foundation entity

Immune reconstitution inflammatory syndrome – http://id.who.int/icd/entity/180703474

Allowed postcoordination axes

Part of: 04: Diseases of the immune system