5A61.5

ICD-11 MMS 2026-01

Central diabetes insipidus

Description

Central diabetes insipidus (CDI) is a hypothalamus-pituitary disease characterised by polyuria and polydipsia due to a vasopressin (AVP) deficiency. The condition may be associated with deficient secretion of antidiuretic hormone (ADH) and is most frequently idiopathic (possibly due to autoimmune injury to the ADH-producing cells), or may be induced by trauma, pituitary surgery, or hypoxic or ischaemic encephalopathy.

Index terms

  • Central diabetes insipidus
  • ADH - [antidiuretic hormone secretion] deficiency
  • DI - [diabetes insipidus]
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  • antidiuretic hormone hyposecretion
  • diabetes insipidus
  • diabetes insipidus secondary to vasopressin deficiency
  • diabetes mellitus insipidus
  • familial diabetes insipidus
  • neurogenic diabetes insipidus
  • primary central diabetes insipidus
  • vasopressin deficiency
  • vasopressin deficiency syndrome
  • vasopressin hyposecretion
  • Wolfram syndrome
  • DIDMOAD - [Diabetes insipidus, diabetes mellitus, optic atrophy, and deafness] syndrome
  • Diabetes insipidus, diabetes mellitus, optic atrophy, and deafness
  • Acquired central diabetes insipidus
  • Acquired central diabetes due to Infiltrative disease
  • Idiopathic acquired central diabetes insipidus
  • Traumatic central diabetes insipidus
  • Non-acquired central diabetes insipidus
  • Cranial diabetes insipidus
  • Neurohypophyseal diabetes insipidus

Inclusions

  • ADH - [antidiuretic hormone secretion] deficiency

Excludes

  • GB90.4A – Nephrogenic diabetes insipidus

Exclusions from above levels

  • 2A00 – Craniopharyngioma
  • 5D43 – Postprocedural hypopituitarism
  • 18 – Pregnancy, childbirth or the puerperium
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  • http://id.who.int/icd/entity/1004987305 – Transitory endocrine or metabolic disorders specific to fetus or newborn

Sibling codes

  • 5A61.0 – Hypopituitarism
  • 5A61.1 – Adrenocorticotropic hormone deficiency
  • 5A61.2 – Gonadotropin deficiency
  • 5A61.3 – Growth hormone deficiency
  • 5A61.4 – Thyroid stimulating hormone deficiency
  • 5A61.6 – Oxytocin deficiency
  • 5A61.Y – Other specified hypofunction or disorders of pituitary gland

Foundation entity

Central diabetes insipidus – http://id.who.int/icd/entity/1009553897

Part of: 5A61: Hypofunction or certain other specified disorders of pituitary gland › 05: Endocrine, nutritional or metabolic diseases