5A81.1

ICD-11 MMS 2026-01

Testicular hypofunction

Description

In pre-puberty, a disorder characterised by atrophied testes and sterility, abnormal height and absence of secondary sex characteristics. In post-puberty, a disorder characterised by depressed sexual function, loss of sex drive and sterility, muscle weakness and osteoporosis (due to loss of the androgen anabolic effect).

Index terms

  • Testicular hypofunction
  • 5-alpha-reductase deficiency
  • 5-alpha-reductase deficiency with male pseudohermaphroditism
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  • Testicular hypogonadism NOS
  • androgen deficiency
  • defect of testicular androgen synthesis
  • deficiency of testicular hormone
  • eunuchoidism
  • gonadal insufficiency of testis
  • hypofunction testicle
  • male hypogonadism
  • prepuberal castrate syndrome
  • testicular hypogonadism
  • undeveloped testis
  • Male infertility due to a systemic disease
  • Male infertility with normal virilization due to a systemic disease
  • Male infertility with normal virilization due to acquired testicular defects
  • Defective biosynthesis of testosterone in aged men
  • Defective biosynthesis of testicular androgen NOS
  • Testicular hypogonadism in aged men
  • defective biosynthesis of testicular androgen
  • deficiency of testosterone biosynthesis
  • Male infertility associated with autoimmunity
  • Male infertility with normal virilisation due to acquired testicular defect associated with autoimmunity
  • Male infertility associated with drug
  • Drug induced testicular hypofunction
  • Male infertility with normal virilisation due to acquired testicular defect associated with drug
  • Male infertility associated with environmental toxin
  • Male infertility with normal virilisation due to acquired testicular defect associated with environmental toxin
  • Male infertility associated with mycoplasma infection
  • Male infertility associated with radiation
  • Male infertility with normal virilisation due to acquired testicular defect associated with radiation
  • Male infertility associated with spinal cord injury
  • Male infertility with normal virilisation due to testicular defect associated with spinal cord injury
  • Male infertility with normal virilization due to developmental or structural testicular defects
  • Chromosome Y deletion
  • Male sterility due to chromosome Y deletion
  • Partial chromosome Y deletion
  • Male infertility associated with cryptorchidism
  • Male infertility with normal virilisation due to developmental or structural testicular defect associated with cryptorchidism
  • Male infertility associated with varicocele
  • Male infertility with normal virilisation due to a developmental or structural testicular defect associated with varicocele
  • Sertoli cell only syndrome

Exclusions from above levels

  • 5A61.0 – isolated gonadotropin deficiency
  • 5D45 – Postprocedural testicular hypofunction
  • GB04.0 – Azoospermia
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  • GB04.Y – Oligospermia
  • LD50.3 – Klinefelter syndrome
  • 18 – Pregnancy, childbirth or the puerperium
  • http://id.who.int/icd/entity/1004987305 – Transitory endocrine or metabolic disorders specific to fetus or newborn

Sibling codes

  • 5A81.0 – Testicular hyperfunction
  • 5A81.Y – Other specified testicular dysfunction or testosterone-related disorders
  • 5A81.Z – Testicular dysfunction or testosterone-related disorders, unspecified

Foundation entity

Testicular hypofunction – http://id.who.int/icd/entity/537070421

Allowed postcoordination axes

Part of: 5A81: Testicular dysfunction or testosterone-related disorders › 05: Endocrine, nutritional or metabolic diseases