6C45.2

ICD-11 MMS 2026-01

Cocaine dependence

Description

Cocaine dependence is a disorder of regulation of cocaine use arising from repeated or continuous use of cocaine. The characteristic feature is a strong internal drive to use cocaine, which is manifested by impaired ability to control use, increasing priority given to use over other activities and persistence of use despite harm or negative consequences. These experiences are often accompanied by a subjective sensation of urge or craving to use cocaine. Physiological features of dependence may also be present, including tolerance to the effects of cocaine, withdrawal symptoms following cessation or reduction in use of cocaine, or repeated use of cocaine or pharmacologically similar substances to prevent or alleviate withdrawal symptoms. The features of dependence are usually evident over a period of at least 12 months but the diagnosis may be made if cocaine use is continuous (daily or almost daily) for at least 3 months.

Excludes

  • 6C45.0 – Episode of harmful use of cocaine
  • 6C45.1 – Harmful pattern of use of cocaine

Exclusions from above levels

  • 6C46 – Disorders due to use of stimulants including amphetamines, methamphetamine or methcathinone
  • QE11.3 – Hazardous use of cocaine
  • QE62 – Uncomplicated bereavement
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  • QE84 – Acute stress reaction

Child codes

  • 6C45.20 – Cocaine dependence, current use
  • 6C45.21 – Cocaine dependence, early full remission
  • 6C45.22 – Cocaine dependence, sustained partial remission
  • 6C45.23 – Cocaine dependence, sustained full remission
  • 6C45.2Z – Cocaine dependence, unspecified

Sibling codes

  • 6C45.0 – Episode of harmful use of cocaine
  • 6C45.1 – Harmful pattern of use of cocaine
  • 6C45.3 – Cocaine intoxication
  • 6C45.4 – Cocaine withdrawal
  • 6C45.5 – Cocaine-induced delirium
  • 6C45.6 – Cocaine-induced psychotic disorder
  • 6C45.7 – Certain specified cocaine-induced mental or behavioural disorders
  • 6C45.Y – Other specified disorders due to use of cocaine
  • 6C45.Z – Disorders due to use of cocaine, unspecified

Foundation entity

Cocaine dependence – http://id.who.int/icd/entity/1691013484

Allowed postcoordination axes

Part of: 6C45: Disorders due to use of cocaine › 06: Mental, behavioural or neurodevelopmental disorders