6C4F.2

ICD-11 MMS 2026-01

Multiple specified psychoactive substances dependence

Description

Multiple specified psychoactive substance dependence is a disorder of regulation of use of multiple specified substances arising from repeated or continuous use of the specified substances. The characteristic feature is a strong internal drive to use the specified substances, which is manifested by impaired ability to control use, increasing priority given to use over other activities and persistence of use despite harm or negative consequences. These experiences are often accompanied by a subjective sensation of urge or craving to use the specified substances. Physiological features of dependence may also be present, including tolerance to the effects of the specified substances, withdrawal symptoms following cessation or reduction in use of the specified substances, or repeated use of the specified substances or pharmacologically similar substances to prevent or alleviate withdrawal symptoms. The features of dependence are usually evident over a period of at least 12 months but the diagnosis may be made if use of the specified substances is continuous (daily or almost daily) for at least 3 months.

Excludes

  • 6C4F.0 – Episode of harmful use of multiple specified psychoactive substances
  • 6C4F.1 – Harmful pattern of use of multiple specified psychoactive substances

Exclusions from above levels

  • QE62 – Uncomplicated bereavement
  • QE84 – Acute stress reaction

Child codes

  • 6C4F.20 – Multiple specified psychoactive substances dependence, current use
  • 6C4F.21 – Multiple specified psychoactive substances dependence, early full remission
  • 6C4F.22 – Multiple specified psychoactive substances dependence, sustained partial remission
  • 6C4F.23 – Multiple specified psychoactive substances dependence, sustained full remission
  • 6C4F.2Z – Multiple specified psychoactive substances dependence, unspecified

Sibling codes

  • 6C4F.0 – Episode of harmful use of multiple specified psychoactive substances
  • 6C4F.1 – Harmful pattern of use of multiple specified psychoactive substances
  • 6C4F.3 – Intoxication due to multiple specified psychoactive substances
  • 6C4F.4 – Multiple specified psychoactive substances withdrawal
  • 6C4F.5 – Delirium induced by multiple specified psychoactive substances including medications
  • 6C4F.6 – Psychotic disorder induced by multiple specified psychoactive substances
  • 6C4F.7 – Certain multiple specified psychoactive substances-induced mental or behavioural disorders
  • 6C4F.Y – Other specified disorders due to use of multiple specified psychoactive substances, including medications
  • 6C4F.Z – Disorders due to use of multiple specified psychoactive substances, including medications, unspecified

Foundation entity

Multiple specified psychoactive substances dependence – http://id.who.int/icd/entity/853273682

Allowed postcoordination axes

Part of: 6C4F: Disorders due to use of multiple specified psychoactive substances, including medications › 06: Mental, behavioural or neurodevelopmental disorders