6C4F.4

ICD-11 MMS 2026-01

Multiple specified psychoactive substances withdrawal

Description

Multiple specified psychoactive substance withdrawal is a clinically significant cluster of symptoms, behaviours and physiological features, varying in degree of severity and duration, that occurs upon cessation or reduction of use of multiple specified substances in individuals who have developed dependence or have used the specified substances for a prolonged period or in large amounts. Multiple specified psychoactive substance withdrawal can also occur when prescribed psychoactive medications have been used in standard therapeutic doses. The specific features of the withdrawal state depend on the pharmacological properties of the specified substances and their interactions.

Exclusions from above levels

  • QE62 – Uncomplicated bereavement
  • QE84 – Acute stress reaction

Child codes

  • 6C4F.40 – Multiple specified psychoactive substances withdrawal, uncomplicated
  • 6C4F.41 – Multiple specified psychoactive substances withdrawal, with perceptual disturbances
  • 6C4F.42 – Multiple specified psychoactive substances withdrawal, with seizures
  • 6C4F.43 – Multiple specified psychoactive substances withdrawal, with perceptual disturbances and seizures
  • 6C4F.4Y – Other specified multiple specified psychoactive substances withdrawal
  • 6C4F.4Z – Multiple specified psychoactive substances withdrawal, unspecified

Sibling codes

  • 6C4F.0 – Episode of harmful use of multiple specified psychoactive substances
  • 6C4F.1 – Harmful pattern of use of multiple specified psychoactive substances
  • 6C4F.2 – Multiple specified psychoactive substances dependence
  • 6C4F.3 – Intoxication due to multiple specified psychoactive substances
  • 6C4F.5 – Delirium induced by multiple specified psychoactive substances including medications
  • 6C4F.6 – Psychotic disorder induced by multiple specified psychoactive substances
  • 6C4F.7 – Certain multiple specified psychoactive substances-induced mental or behavioural disorders
  • 6C4F.Y – Other specified disorders due to use of multiple specified psychoactive substances, including medications
  • 6C4F.Z – Disorders due to use of multiple specified psychoactive substances, including medications, unspecified

Foundation entity

Multiple specified psychoactive substances withdrawal – http://id.who.int/icd/entity/1583329300

Allowed postcoordination axes

Part of: 6C4F: Disorders due to use of multiple specified psychoactive substances, including medications › 06: Mental, behavioural or neurodevelopmental disorders