8A00.01

ICD-11 MMS 2026-01

Familial Parkinson disease

Description

Familial subtype of Parkinson Disease, a disorder caused by progressive dopaminergic neuron degeneration of the substantia nigra that is characterized by resting tremor, bradykinesia, and rigidity. Familial cases can be caused by mutations in LRRK2, PARK7, PINK1, PRKN, or SNCA genes.

Index terms

  • Familial Parkinson disease
  • Other genetic Parkinsonism
  • Autosomal dominant familial Parkinson disease
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  • Parkinson disease LRRK2 gene mutation 12p11.23-q13.11
  • PARK8
  • Parkinson disease synuclein gene mutation 4q21.23
  • PARK1
  • Parkinson disease synduclein duplications or triplications
  • Parkinson disease UCHL-1 gene mutations 4p14
  • PARK5
  • Autosomal recessive familial Parkinson disease
  • Parkinson disease parkin mutations
  • PARK 2
  • Parkinson disease DJ-1 gene mutations 1p36
  • PARK 7
  • Parkinson disease PINK gene mutations
  • PARK 6
  • PINK 1
  • Parkinson disease ATP13A2 mutations

Exclusions from above levels

  • http://id.who.int/icd/entity/1425591047 – Myasthenia gravis or certain specified neuromuscular junction disorders
  • http://id.who.int/icd/entity/1525792972 – Arthropathies
  • 6A06 – Stereotyped movement disorder
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  • 05 – Endocrine, nutritional or metabolic diseases
  • 18 – Complications of pregnancy, childbirth and the puerperium
  • 19 – Certain conditions originating in the perinatal period
  • 22 – Injury, poisoning or certain other consequences of external causes

Sibling codes

  • 8A00.00 – Sporadic Parkinson disease
  • 8A00.0Y – Other specified Parkinson disease
  • 8A00.0Z – Parkinson disease, unspecified

Foundation entity

Familial Parkinson disease – http://id.who.int/icd/entity/811427861

Allowed postcoordination axes

Part of: 8A00.0: Parkinson disease › 8A00: Parkinsonism › 08: Diseases of the nervous system