Autoimmune myopathy

Description

Autoimmune myopathy is a subgroup of idiopathic inflammatory myopathies, which, despite diverse causes, have the common histopathological features of myocyte necrosis without significant inflammation. Patients present with a subacute severe symmetrical proximal myopathy, associated with a markedly elevated creatine kinase level. These are most likely immune-mediated, as they respond to immunotherapy. It is often accompanied by statin therapy, connective tissue diseases, cancer, and autoantibodies specific for signal recognition particle (SRP) or 3-hydroxy-3-methylglutaryl–coenzyme A reductase (HMGCR).

Index terms

Autoimmune myopathy

Excludes

http://id.who.int/icd/entity/1425591047 – Myasthenia gravis or certain specified neuromuscular junction disorders
http://id.who.int/icd/entity/833816211 – Primary disorders of muscles

Exclusions from above levels

FB32.2 – Ischaemic infarction of muscle
LD26.41 – Arthrogryposis multiplex congenita
05 – Endocrine, nutritional or metabolic diseases

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18 – Complications of pregnancy, childbirth and the puerperium
19 – Certain conditions originating in the perinatal period
22 – Injury, poisoning or certain other consequences of external causes

Sibling codes

8C80 – Drug-induced myopathy
8C82 – Myopathy in certain specified infectious or parasitic disease
8C83 – Myopathy in certain specified endocrine disease
8C84 – Secondary rhabdomyolysis
8C8Y – Other specified secondary myopathies
8C8Z – Secondary myopathies, unspecified

Foundation entity

Autoimmune myopathy – http://id.who.int/icd/entity/1227790808

Allowed postcoordination axes

Part of: 08: Diseases of the nervous system