8E40.0

ICD-11 MMS 2026-01

Neoplastic meningitis

Description

Inflammation of the meninges due to malignant infiltration from carcinomas, leukaemias and lymphomas. The syndrome is clinically characterised by headache, neck stiffness, fever and photophobia with potential progression to stupor and coma. The presentation may be acute, subacute or chronic. Diagnosis may be aided by neuroimaging and spinal fluid analysis which may reveal a lymphocytic pleocytosis, raised protein and the presence of malignant cells on cytology.

Index terms

  • Neoplastic meningitis
  • Malignant meningitis
  • Carcinomatous meningitis
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  • Leukemic meningitis
  • Lymphomatous meningitis

Exclusions from above levels

  • 05 – Endocrine, nutritional or metabolic diseases
  • 18 – Complications of pregnancy, childbirth and the puerperium
  • 19 – Certain conditions originating in the perinatal period
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  • 22 – Injury, poisoning or certain other consequences of external causes

Sibling codes

  • 8E40.1 – Chemical meningitis
  • 8E40.2 – Inflammatory meningitis
  • 8E40.3 – Arachnoiditis
  • 8E40.Y – Other specified disorders of the meninges excluding infection
  • 8E40.Z – Disorders of the meninges excluding infection, unspecified

Foundation entity

Neoplastic meningitis – http://id.who.int/icd/entity/262966673

Allowed postcoordination axes

Part of: 8E40: Disorders of the meninges excluding infection › 08: Diseases of the nervous system