8E46

ICD-11 MMS 2026-01

Reye syndrome

Description

Reye syndrome is sudden (acute) brain damage (encephalopathy) and liver function problems of unknown cause. The syndrome has occurred with the use of aspirin to treat chickenpox or the flu in children. However, it has become very uncommon since aspirin is no longer recommended for routine use in children. Reye syndrome often begins with vomiting, which lasts for many hours. The vomiting is quickly followed by irritable and aggressive behaviour. There is no specific treatment for this condition. The health care provider will monitor the pressure in the brain, blood gases, and blood acid-base balance (pH).

Index terms

  • Reye syndrome
  • Reye encephalopathy
  • fatty liver with encephalopathy
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  • liver fatty metamorphosis--acute encephalopathy syndrome

Exclusions from above levels

  • 05 – Endocrine, nutritional or metabolic diseases
  • 18 – Complications of pregnancy, childbirth and the puerperium
  • 19 – Certain conditions originating in the perinatal period
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  • 22 – Injury, poisoning or certain other consequences of external causes

Sibling codes

  • 8E40 – Disorders of the meninges excluding infection
  • 8E41 – Pachymeningitis
  • 8E42 – Superficial siderosis of the nervous system
  • 8E43 – Pain disorders
  • 8E44 – Post anoxic brain damage
  • 8E45 – Locked-in syndrome
  • 8E47 – Encephalopathy, not elsewhere classified
  • 8E48 – Encephalitis, not elsewhere classified
  • 8E49 – Postviral fatigue syndrome
  • 8E4A – Paraneoplastic or autoimmune disorders of the nervous system

Foundation entity

Reye syndrome – http://id.who.int/icd/entity/649014905

Part of: 08: Diseases of the nervous system