EB13.1

ICD-11 MMS 2026-01

Toxic epidermal necrolysis

Description

Toxic epidermal necrolysis (TEN) is an acute life-threatening skin disease with commonly quoted overall risk of mortality of between 25 and 30%, though the risk of fatal outcome is around 90% in the most severely affected patients (SCORTEN score >5). It is characterised by the rapid onset of extensive erythema, necrosis, and bullous detachment of the epidermis (> 30% body surface area). Commonly, the mucous membranes are also involved. Death may result from a combination of sepsis, fluid depletion and multi-organ failure. In two thirds of cases, TEN is triggered by a clearly identifiable drug allergy.

Index terms

  • Toxic epidermal necrolysis
  • Lyell syndrome
  • Lyell syndrome (toxic epidermal necrolysis)
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  • TEN - [toxic epidermal necrolysis]

Exclusions from above levels

  • 1B72.0 – Bullous impetigo of the napkin area
  • 1F23.12 – Napkin candidosis
  • EH71 – Dermatoses precipitated by drug therapy
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  • EH76 – Dermatoses associated with specific classes of medication

Foundation children elsewhere

  • EH63.1 – Drug-induced toxic epidermal necrolysis

Sibling codes

  • EB13.0 – Stevens-Johnson syndrome
  • EB13.2 – Stevens-Johnson and toxic epidermal necrolysis overlap syndrome

Foundation entity

Toxic epidermal necrolysis – http://id.who.int/icd/entity/1575072695

Part of: EB13: Stevens-Johnson syndrome or toxic epidermal necrolysis › 14: Diseases of the skin