Disseminated paracoccidioidomycosis

Description

Disseminated paracoccidioidomycosis results from haematogenous and lymphatic dissemination of yeasts from the lungs and aerodigestive tract. Cutaneous involvement, seen in 25% of cases, presents as crusted papules, ulcers, nodules, and verrucous plaques. Lymphadenopathy occurs commonly in the cervical region, but all lymph node chains can be involved. Adrenal glands are commonly affected with a significant risk of adrenal insufficiency and Addisonian crisis. Long bones such as ribs, humeri, and clavicles can be involved. Mesenteric lymph node involvement can lead to bowel obstruction. Meningoencephalitis occurs in up to one quarter of cases.

Inclusions

• Disseminated paracoccidioidomycosis with central nervous system involvement
• Disseminated paracoccidioidomycosis without central nervous system involvement

Exclusions from above levels

• 2B01 – Mycosis fungoides
• CA70 – Hypersensitivity pneumonitis due to organic dust
• NE83.1 – Infection arising from device, implant or graft, not elsewhere classified