Gamma heavy chain disease

Description

A clonal disorder characterised by the secretion of a truncated gamma chain. In most cases, it is associated with morphologic changes also seen in lymphoplasmacytic lymphomas, but the clinical course is typically more aggressive than in lymphoplasmacytic lymphoma/Waldenstrom's macroglobulinemia.

Inclusions

• Franklin disease

Exclusions from above levels

• 2E03 – Malignant neoplasm metastasis in bone or bone marrow
• http://id.who.int/icd/entity/501778925 – Malignant neoplasm metastasis in lymph nodes
• http://id.who.int/icd/entity/97145147 – Malignant neoplasm metastasis in thymus gland