3A20.1

ICD-11 MMS 2026-01

Autoimmune haemolytic anaemia, cold type

Description

Cold autoimmune haemolytic anaemia comprises two types of autoimmune haemolytic anaemia (AIHA) defined by the presence of cold autoantibodies (autoantibodies which are active at temperatures below 30°C): cold agglutinin disease (CAD), which is the more common, and paroxysmal cold haemoglobinuria (PCH). CAD is more common in people over the age of 55 years, while PCH typically presents in young children. CAD is caused by IgM autoantibodies while PCH is caused by an IgG immunoglobulin.

Index terms

  • Autoimmune haemolytic anaemia, cold type
  • autoimmune cold sense
  • autoimmune cold sensitivity
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  • autoimmune haemolytic anaemia due to cold antibodies
  • cold antibody haemolytic anaemia
  • cold autoimmune haemolytic anaemia
  • cold haemolytic disease
  • cryopathic haemolytic anaemia
  • idiopathic cold autoimmune haemolytic anaemia
  • secondary cold type haemolytic anaemia
  • symptomatic cold type haemolytic anaemia
  • Cold haemagglutinin disease
  • CHAD - [cold hemagglutinin disease]
  • Cold agglutinin disease
  • Cold agglutinin haemoglobinuria
  • cold agglutinin disease or haemoglobinuria
  • cold hemagglutinin disease

Inclusions

  • Cold haemagglutinin disease

Excludes

  • 3B64.10 – Immune thrombocytopenic purpura
  • KA84 – Haemolytic disease of fetus or newborn

Exclusions from above levels

  • 04 – Diseases of the immune system
  • 05 – Endocrine, nutritional or metabolic diseases
  • 18 – Complications of pregnancy, childbirth or the puerperium
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  • 19 – Certain conditions originating in the perinatal period
  • 20 – Congenital malformations, deformations or chromosomal abnormalities
  • 22 – Injury, poisoning or certain other consequences of external causes
  • http://id.who.int/icd/entity/1000704511 – Human immunodeficiency virus disease
  • JB64.1 – Other diseases of the blood or blood-forming organs or certain disorders involving the immune mechanism complicating pregnancy, childbirth or the puerperium

Sibling codes

  • 3A20.0 – Autoimmune haemolytic anaemia, warm type
  • 3A20.2 – Autoimmune haemolytic anaemia, mixed type, cold and warm
  • 3A20.3 – Paroxysmal cold haemoglobinuria
  • 3A20.4 – Alloimmune haemolytic anaemia
  • 3A20.5 – Evans syndrome
  • 3A20.Y – Other specified acquired haemolytic anaemia, immune
  • 3A20.Z – Acquired haemolytic anaemia, immune, unspecified

Foundation entity

Autoimmune haemolytic anaemia, cold type – http://id.who.int/icd/entity/1836938544

Part of: 3A20: Acquired haemolytic anaemia, immune › 03: Diseases of the blood or blood-forming organs