Syndrome of inappropriate secretion of antidiuretic hormone

Description

Syndrome of inappropriate antidiuretic hormone (ADH) secretion (SIADH) is characterised by continued ADH secretion, leading to hyponatremia, hypoosmolality and natriuresis. Exact prevalence is unknown. The disease has been described in all age groups. SIADH is often associated with tumours, pulmonary disease, central nervous system disorders or exposure to drugs. Occasionally, it is found in patients with adrenal, thyroid or pituitary insufficiency. The disorder is caused by gain-of-function mutations in the gene encoding the vasopressin V2 receptor. Fluid restriction is the most common treatment. The outcome is related to the underlying and associated disorders.

Exclusions from above levels

2F7A.0 – Multiple endocrine neoplasia type 4
5A02.Y – overproduction of thyroid-stimulating hormone
5A70 – Cushing syndrome

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5A70.0 – overproduction of pituitary ACTH
5A70.3 – Nelson syndrome
18 – Pregnancy, childbirth or the puerperium
http://id.who.int/icd/entity/1004987305 – Transitory endocrine or metabolic disorders specific to fetus or newborn

Child codes

5A60.20 – Nephrogenic syndrome of inappropriate antidiuresis
5A60.2Y – Other specified syndrome of inappropriate secretion of antidiuretic hormone
5A60.2Z – Syndrome of inappropriate secretion of antidiuretic hormone, unspecified

Sibling codes

5A60.0 – Acromegaly or pituitary gigantism
5A60.1 – Hyperprolactinaemia
5A60.3 – Central precocious puberty
5A60.Y – Other specified hyperfunction of pituitary gland
5A60.Z – Hyperfunction of pituitary gland, unspecified

Foundation entity

Syndrome of inappropriate secretion of antidiuretic hormone – http://id.who.int/icd/entity/550787432

Part of: 5A60: Hyperfunction of pituitary gland › 05: Endocrine, nutritional or metabolic diseases