6C43.4ICD-11 MMS 2026-01
Opioid withdrawal
Description
Opioid withdrawal is a clinically significant cluster of symptoms, behaviours and/or physiological features, varying in degree of severity and duration, that occurs upon cessation or reduction of use of opioids in individuals who have developed Opioid dependence or have used opioids for a prolonged period or in large amounts. Opioid withdrawal can also occur when prescribed opioids have been used in standard therapeutic doses. Presenting features of Opioid withdrawal may include dysphoric mood, craving for an opioid, anxiety, nausea or vomiting, abdominal cramps, muscle aches, yawning, perspiration, hot and cold flushes, lacrimation, rhinorrhea, hypersomnia (typically in the initial phase) or insomnia, diarrhea, piloerection, and pupillary dilatation.
Index terms
- Opioid withdrawal
- Opioid withdrawal, uncomplicated
- Opioid withdrawal, with seizures
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- Codeine withdrawal
- Heroin withdrawal
Exclusions from above levels
Sibling codes
6C43.0– Episode of harmful use of opioids6C43.1– Harmful pattern of use of opioids6C43.2– Opioid dependence6C43.3– Opioid intoxication6C43.5– Opioid-induced delirium6C43.6– Opioid-induced psychotic disorder6C43.7– Certain specified opioid-induced mental or behavioural disorders6C43.Y– Other specified disorders due to use of opioids6C43.Z– Disorders due to use of opioids, unspecified
Foundation entity
Allowed postcoordination axes
Part of: 6C43: Disorders due to use of opioids › 06: Mental, behavioural or neurodevelopmental disorders