6C43.4

ICD-11 MMS 2026-01

Opioid withdrawal

Description

Opioid withdrawal is a clinically significant cluster of symptoms, behaviours and/or physiological features, varying in degree of severity and duration, that occurs upon cessation or reduction of use of opioids in individuals who have developed Opioid dependence or have used opioids for a prolonged period or in large amounts. Opioid withdrawal can also occur when prescribed opioids have been used in standard therapeutic doses. Presenting features of Opioid withdrawal may include dysphoric mood, craving for an opioid, anxiety, nausea or vomiting, abdominal cramps, muscle aches, yawning, perspiration, hot and cold flushes, lacrimation, rhinorrhea, hypersomnia (typically in the initial phase) or insomnia, diarrhea, piloerection, and pupillary dilatation.

Index terms

  • Opioid withdrawal
  • Opioid withdrawal, uncomplicated
  • Opioid withdrawal, with seizures
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  • Codeine withdrawal
  • Heroin withdrawal

Exclusions from above levels

  • QE11.0 – Hazardous use of opioids
  • QE62 – Uncomplicated bereavement
  • QE84 – Acute stress reaction

Sibling codes

  • 6C43.0 – Episode of harmful use of opioids
  • 6C43.1 – Harmful pattern of use of opioids
  • 6C43.2 – Opioid dependence
  • 6C43.3 – Opioid intoxication
  • 6C43.5 – Opioid-induced delirium
  • 6C43.6 – Opioid-induced psychotic disorder
  • 6C43.7 – Certain specified opioid-induced mental or behavioural disorders
  • 6C43.Y – Other specified disorders due to use of opioids
  • 6C43.Z – Disorders due to use of opioids, unspecified

Foundation entity

Opioid withdrawal – http://id.who.int/icd/entity/663160065

Allowed postcoordination axes

Part of: 6C43: Disorders due to use of opioids › 06: Mental, behavioural or neurodevelopmental disorders